Glial Adhesion Cytoskeletal
Gene co-expression module in Glial cells
| Category | migration & adhesion |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
NCAM1 encodes a neural cell adhesion molecule critical for glial and neuronal interactions. EPB41L2 links spectrin-actin cytoskeleton to the membrane. SORBS2 is a cytoskeletal adapter involved in actin organization. COL21A1 is a fibrillar collagen expressed in neural tissues. SCN7A encodes a sodium channel expressed in glia (Nav2.1). LTBP3 is a latent TGF-β binding protein in ECM. RALGPS2 activates Ral GTPases involved in vesicle trafficking. AKAP9 scaffolds kinases at cytoskeletal structures. DOCK5 is a Rac GEF. KIAA1217/SICKLE is involved in ciliogenesis. The module combines neural adhesion and cytoskeletal scaffolding themes, significantly downregulated in UC inflammation and restored in remission. Neighbor context with M68 and M67 supports a glial homeostatic adhesion/cytoskeletal neighborhood.
Genes
AKAP9, COL21A1, DOCK5, EPB41L2, KIAA1217, LTBP3, NCAM1, RALGPS2, SCN7A, SORBS2
Most correlated modules
- Matricellular ECM Homeostasis · correlation 0.91
- Neural Migration Scaffold · correlation 0.91
- Glial Synaptic Adhesion · correlation 0.89
- Peripheral Nerve Myelination · correlation 0.81
- RNA Splicing Regulation · correlation 0.77
- Neuroprotective Secretory · correlation 0.76
- Glial Homeostatic Identity · correlation 0.73
- Enteric Glial Identity · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.