SCUBA

VPS13C — Vacuolar protein sorting 13 homolog C

VPS13C belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

VPS13C's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsChromatin Regulation
DNA/chromatin regulation
AKAP9, ANKRD12, BBX, CHD2, CHD7, IRF1, KDM7A, L3MBTL3 +8 moreView in SCUBA
CD4⁺ T cellsCCR5 effector migration
migration & adhesion
ARHGEF12, BLM, CCR5, EMC6, ERGIC2, IGF2R, KAT2B, PSMD12 +10 moreView in SCUBA
EndothelialNF-κB Stress Signaling
Inflammation
AKR1C3, ELK4, EPS15, METRNL, MYCBP2, NFAT5, PALM, PELI2 +4 moreView in SCUBA
EnterocytesLong-gene intronic signal
Technical artifact
ASCC3, CASK, KCNQ1, LGR4, MAP3K5, MECOM, MID1, PPP1R9A +5 moreView in SCUBA
Gamma-delta T cellsChromatin Epigenetic Regulation
DNA/chromatin regulation
ACIN1, ASH1L, BDP1, BLTP1, CLTC, EPS15, EXOC2, FAM120B +24 more
Glial cellsRNA Splicing Regulation
RNA processing & translation
ARGLU1, COL16A1, DDX17, DST, LUC7L3, N4BP2L2, NRBP2, PNISR +2 moreView in SCUBA
Lymphatic endothelialPre-mRNA Splicing
RNA processing & translation
ARGLU1, ATRX, BPTF, DDX17, DST, LUC7L3, N4BP2L2, NKTR +6 moreView in SCUBA
MacrophagesPost-transcriptional Regulation
Housekeeping
AKAP10, ATF7IP, ATRN, ATXN2, BAZ2B, BLTP1, BRWD1, CELF2 +34 moreView in SCUBA
Mucosal-associated invariant T cellHistone Modification
DNA/chromatin regulation
ANKRD17, ARHGEF6, ASH1L, CLTC, FAM120B, KDM4C, NRDC, PCM1 +3 more
NeutrophilsmRNA Splicing Processing
Housekeeping
ABCA13, ATP2A3, EMB, FBXO9, LUC7L3, NKTR, OGT, PAXBP1 +8 more

About the gene

SynonymsBLTP5C, FLJ10381, FLJ20136, KIAA1421
Chromosome15: 61852389-62060473
Predicted locationIntracellular
Essential geneNo
Protein classDisease related genes, Human disease related genes, Predicted intracellular proteins
Biological processLipid transport, Transport

Function

Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN- mediated mitophagy in response to mitochondrial depolarization.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.