Glial RNA Homeostasis
Gene co-expression module in Glial cells
| Category | RNA processing & translation |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include DYNC1H1 (cytoplasmic dynein, axonal transport), SCN9A (Nav1.7 sodium channel, enteric neuron/glia), SYNM (synemin, intermediate filament expressed in glia), alongside RNA splicing factors SRSF11 and RBM25, and chromatin regulator ATRX. Uniform expression across subsets; decreases with UC inflammation and recovers in remission. Module combines neuronal cytoskeletal/transport identity with RNA processing, consistent with homeostatic enteric glial transcriptional maintenance. Neighbor M17 is a pure splicing module, suggesting co-expression network edge driven by shared RNA processing program.
Genes
ATRX, DYNC1H1, GTF2I, NCL, RBM25, SCN9A, SRSF11, SYNM
Most correlated modules
- Glial Homeostatic Identity · correlation 0.83
- Basement Membrane Adhesion · correlation 0.81
- Actin Remodeling Migration · correlation 0.80
- ECM Homeostatic Regulation · correlation 0.76
- Glial Adhesion Identity · correlation 0.76
- AHR-Cytokine Activation · correlation 0.74
- Peripheral Nerve Myelination · correlation 0.74
- Glial Synaptic Adhesion · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.