Epithelial Differentiation Metabolism
Gene co-expression module in Goblet cells
| Category | Epithelial development |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include PRSS3 (epithelial serine protease), PKM (glycolytic enzyme supporting differentiated cell metabolism), GOLM1 (Golgi membrane protein in secretory pathway), TSPAN8 (epithelial differentiation marker), TMEM45B and TMEM54 (transmembrane proteins associated with epithelial maturation), AKR1C3 (metabolic reductase in differentiated epithelium), and BSG (lactate transporter chaperone). All genes show uniform expression with no contamination signal. Together they define a mature differentiated goblet/colonocyte metabolic and structural program, upregulated upon CD treatment — consistent with restoration of epithelial differentiation.
Genes
AKR1C3, BSG, GOLM1, PKM, PRSS3, TMEM45B, TMEM54, TSPAN8
Most correlated modules
- Mucosal Antibacterial Defense · correlation 0.62
- Mucosal Innate Defense · correlation 0.60
- Glutathione Detoxification · correlation 0.59
- Mature Colonocyte Function · correlation 0.55
- Epithelial Membrane Identity · correlation 0.46
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.