Mature Colonocyte Function
Gene co-expression module in Goblet cells
| Category | Epithelial development |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
CFTR (cystic fibrosis transmembrane conductance regulator) is a chloride/bicarbonate channel expressed in colonocytes and goblet cells, essential for fluid/mucus secretion. SELENBP1 is consistently identified as a colonocyte differentiation marker, strongly down in colorectal cancer and IBD. NOX1 (NADPH oxidase 1) is expressed specifically in the colon epithelium. PLBD1 is a lipase/phospholipase expressed in differentiated epithelium. MAOA metabolizes monoamines in the intestine. PDCD4 is a tumor suppressor. LEFTY1 is a TGF-β superfamily member. ADD3 is a cytoskeletal protein. CERS6 synthesizes ceramides. GAS6 activates TAM receptors. The combination of CFTR, SELENBP1, and NOX1 strongly anchors this module to mature colonocyte/goblet differentiated function, consistent with the inflammation-down, remission-up pattern.
Genes
ADD3, CERS6, CFTR, GAS6, LEFTY1, MAOA, NOX1, PDCD4, PLBD1, PTPRO, SELENBP1
Most correlated modules
- Anti-inflammatory Lipid Signaling · correlation 0.76
- Colonocyte Differentiation Program · correlation 0.73
- Notch Secretory Specification · correlation 0.71
- Colonocyte Metabolic Defense · correlation 0.68
- Mitochondrial Metabolism · correlation 0.67
- mRNA Translation Initiation · correlation 0.64
- Co-translational Chaperone · correlation 0.59
- Epithelial Differentiation Metabolism · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.