Epithelial Membrane Identity
Gene co-expression module in Goblet cells
| Category | Epithelial development |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
EPCAM is a canonical epithelial cell identity and adhesion marker. TMEM176A and TMEM176B are transmembrane proteins associated with vesicular acidification and epithelial differentiation. ITM2B is an integral membrane protein involved in membrane trafficking. RAC1 (Rho GTPase) and PDLIM1 (PDZ-LIM domain cytoskeletal scaffold) reflect epithelial cytoskeletal organization and cell-cell junction maintenance. TPT1 (TCTP) supports cell growth and cytoskeletal integrity. TMEM59 participates in endolysosomal trafficking. SLC25A3 and EIF3H are peripheral housekeeping members. Topological proximity to M97/M56 is explained by shared high-detection housekeeping expression; the specific EPCAM/TMEM176A-B axis marks this as an epithelial membrane identity program distinct from pure translation.
Genes
EIF3H, EPCAM, ITM2B, PDLIM1, RAC1, SLC25A3, TMEM176A, TMEM176B, TMEM59, TPT1
Most correlated modules
- Co-translational Chaperone · correlation 0.76
- mRNA Translation Initiation · correlation 0.65
- Epithelial Maintenance · correlation 0.61
- Oxidative Phosphorylation · correlation 0.59
- Actin Dynamics · correlation 0.57
- Epithelial Junction Integrity · correlation 0.48
- Epithelial Differentiation Metabolism · correlation 0.46
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.