Glutathione Detoxification
Gene co-expression module in Goblet cells
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes: GSTP1 (glutathione S-transferase Pi, detoxification/antioxidant), MGST3 and MGST1 (microsomal glutathione transferases), TXN (thioredoxin, redox regulation), HINT1 (histidine triad nucleotide-binding protein, stress signaling), TST (thiosulfate sulfurtransferase, mitochondrial cyanide/sulfur detox). These genes collectively define a glutathione-based and thioredoxin-based oxidative stress response/detoxification program. EIF3K (translation initiation), SLIRP (mitochondrial RNA stability), SNRPD2 (spliceosomal), and HMGA1 (chromatin) are peripheral. Module is downregulated in inflammation and recovers. Neighbor context: flanked by mitochondrial/OxPhos modules, but M15's focus on glutathione transferases and thioredoxin is clearly a cellular detoxification/antioxidant program distinct from pure electron transport. The neighborhood supports a stress/ROS-defense interpretation.
Genes
EIF3K, GSTP1, HINT1, HMGA1, MGST1, MGST3, SLIRP, SNRPD2, TST, TXN
Most correlated modules
- Mitochondrial Metabolism · correlation 0.80
- Oxidative Phosphorylation · correlation 0.79
- Mitochondrial OxPhos · correlation 0.74
- Mitochondrial Homeostasis · correlation 0.73
- Mitochondrial OxPhos · correlation 0.70
- Oxidative Phosphorylation · correlation 0.67
- SR Splicing Factors · correlation 0.63
- CCT Chaperonin Complex · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.