TMEM45B — Transmembrane protein 45B
TMEM45B belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM45B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Mature colonocyte metabolism Nutrient metabolism | ANXA4, ASS1, ATP1B3, BTNL3, CORO2A, HMCN2, MGAT4A, MOB3B +6 more | View in SCUBA |
| Goblet cells | Epithelial Differentiation Metabolism Epithelial development | AKR1C3, BSG, GOLM1, PKM, PRSS3, TMEM54, TSPAN8 | View in SCUBA |
About the gene
| Synonyms | BC016153, FLJ40787 |
|---|---|
| Chromosome | 11: 129815848-129860003 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Biological process | Immunity, Innate immunity |
Function
Plays a role in innate immunity. Mechanistically, promotes alphaviruses RNA degradation by interacting with the viral polymerase nsP4 and the mRNA-capping enzyme nsP1 and thereby interfering with the interaction between viral RNA and nsP1
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.