Mucosal Innate Defense
Gene co-expression module in Goblet cells
| Category | Immune function |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
This moderate-coherence module contains a heterogeneous set of genes. Hub genes include TKT (transketolase, pentose phosphate pathway), ENO1 (glycolysis), GPI (glycolysis), PPA1 (pyrophosphatase, housekeeping metabolism), and VDAC1 (mitochondrial membrane). Innate defense/secretory genes are also present: PIGR (polymeric immunoglobulin receptor, transepithelial IgA transport), DMBT1 (scavenger receptor, mucosal defense), PLA2G2A (secreted phospholipase, antibacterial), OLFM4 (goblet/stem cell marker), LGALS3BP (lectin), CTSS (cathepsin S, lysosomal protease), BOLA3 (Fe-S cluster), and PRDX1 (peroxiredoxin). The mild but significant upregulation in inflammation suggests a mixed housekeeping/secretory defense module. Given the moderate coherence and mix of metabolic and secretory innate defense genes in goblet cells, this most likely represents a basal goblet cell secretory/defense program combining metabolic support with innate mucosal barrier functions. The dominant signal is mucosal innate defense (PIGR, DMBT1, PLA2G2A, OLFM4, LGALS3BP, CTSS).
Genes
BOLA3, CTSS, DMBT1, ENO1, GPI, LGALS3BP, OLFM4, PIGR, PLA2G2A, PPA1, PRDX1, TKT, VDAC1
Most correlated modules
- Ubiquitin-Proteasome Degradation · correlation 0.67
- MHC Class II Antigen Presentation · correlation 0.67
- Nucleotide Metabolism Stress · correlation 0.64
- Proteostasis Housekeeping · correlation 0.63
- Mitochondrial OxPhos · correlation 0.63
- Pyroptosis Stress Response · correlation 0.62
- Epithelial Differentiation Metabolism · correlation 0.60
- MHC Class I Antigen Presentation · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.