Innate Immune Dampening
Gene co-expression module in Macrophages
| Category | Innate immunity |
|---|---|
| Genes | 19 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 19 genes have a known function matching the annotation |
Why this annotation
Key hub genes include IRAK3 (negative regulator of TLR/IL-1R signaling, anti-inflammatory), PTK2B (focal adhesion/signaling kinase), FKBP5 (glucocorticoid-responsive stress protein), PPARD (PPAR-delta, anti-inflammatory lipid metabolism), PDE8A (cAMP phosphodiesterase, dampens inflammatory signaling), SERINC5 (antiviral restriction), RNF144B (ubiquitin ligase). The module is enriched in mono_mac. In the context of neighboring M110 (NF-κB inflammatory activation), IRAK3 and PPARD suggest this module represents negative regulation/resolution of innate immune signaling — a counter-regulatory program to active inflammation.
Genes
DCAF6, ELL2, FGD4, FKBP5, IRAK3, MAP2K4, MOB3B, PACSIN2, PAPSS2, PDE8A, PPARD, PTK2B, RASSF3, RNF144B, SEC24B, SERINC5, SND1, SNX8, STK10
Most correlated modules
- Rho GTPase Signaling · correlation 0.97
- Endosomal Vesicle Trafficking · correlation 0.97
- Rho GTPase Signaling · correlation 0.96
- MITF Lysosomal Program · correlation 0.96
- Ubiquitin Proteasome Regulation · correlation 0.96
- Chromatin Epigenetic Regulation · correlation 0.95
- Golgi Vesicle Trafficking · correlation 0.95
- Transcriptional Regulation · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.