ER Stress Response
Gene co-expression module in Macrophages
| Category | Stress |
|---|---|
| Genes | 23 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 23 genes have a known function matching the annotation |
Why this annotation
ERN1 (IRE1α) is the primary ER stress sensor and initiator of the unfolded protein response (UPR). ERO1B is an ER oxidoreductase that promotes oxidative protein folding and is upregulated during ER stress. These two genes form a coherent ER stress sub-theme. The remaining genes are functionally diverse (cytoskeletal: UTRN, DST, CLIP2, FNBP1; DNA damage: RNF168; calcium signaling: ITPR2; nuclear pore: POM121), consistent with the weak coherence and unknown module quality. Given the neighbor context of loosely defined regulatory modules, this likely captures a mixed low-coherence program with an ER stress component as the most identifiable biological signal.
Genes
ARHGEF12, ATXN7, BTBD7, CD2AP, CLIP2, DAPK1, DST, ERN1, ERO1B, FNBP1, HOMER1, ITPR2, MSL2, POM121, RNF168, SASH1, SCAF4, TCF4, USPL1, UTRN, ZNF131, ZNF141, ZNF592
Most correlated modules
- Transcriptional Regulation · correlation 0.96
- DNA Damage Response · correlation 0.96
- Chromatin Epigenetic Regulation · correlation 0.95
- Post-transcriptional Regulation · correlation 0.94
- Epigenetic Remodeling · correlation 0.93
- Ubiquitin Proteasome Regulation · correlation 0.93
- Chromatin Remodeling · correlation 0.93
- DNA Damage Repair · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.