Chromatin Epigenetic Regulation
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 30 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 30 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by chromatin modifiers and epigenetic regulators: SETD2 (H3K36 methyltransferase), KDM4B (histone demethylase), RCOR1 (REST corepressor), PHF20 (chromatin reader), ZMYM2 (transcriptional repressor), NCOA3 (nuclear receptor coactivator), FOXO3 (stress-responsive TF). All genes show weak membership and unknown coherence, suggesting a loosely co-regulated epigenetic/transcriptional regulatory program in mono_mac cells. In the context of neighboring inflammatory modules (M110, M130), this likely represents chromatin-level regulation of macrophage transcriptional states.
Genes
ABHD17B, ANKH, ARHGAP21, CCNH, CTTNBP2NL, DMXL1, EEIG2, ELF2, FBXO34, FOXN3, FOXO3, KDM4B, KIF1B, MANBA, NCOA3, NEDD4L, NGLY1, OGT, PDZD8, PHF20, PIKFYVE, RCOR1, RLF, SETD2, SNX9, TMEM131, USP37, ZMYM2, ZNF277, ZZEF1
Most correlated modules
- Rho GTPase Signaling · correlation 0.98
- Ubiquitin Proteasome Regulation · correlation 0.97
- Epigenetic Remodeling · correlation 0.96
- Rho GTPase Signaling · correlation 0.96
- Transcriptional Regulation · correlation 0.96
- Innate Immune Dampening · correlation 0.95
- ER Stress Response · correlation 0.95
- NF-κB Inflammatory Activation · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.