MHC-II Antigen Presentation
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 24 genes have a known function matching the annotation |
Why this annotation
This module contains HLA-DPA1 and HLA-DRA as top hub genes (MHC class II molecules), alongside PSMA4 (proteasome subunit), RBX1 (ubiquitin ligase), BLOC1S1 (lysosomal biogenesis), ATP6V1D (vacuolar ATPase), CHMP5 (ESCRT/endosomal sorting), SPCS2 (signal peptidase), and CALM3 (calmodulin). The combination of MHC-II antigen presentation machinery, proteasomal degradation, lysosomal/endosomal components, and vesicle trafficking suggests antigen processing and presentation. DYNC1I2 (dynein, vesicle transport), MYO1C (myosin, membrane trafficking), and METTL7A are consistent with this program. The module is uniformly expressed across subsets with low mean expression, suggesting a baseline housekeeping-like antigen presentation program in mast cells. Neighbor modules M171 and M146 are cell cycle modules, suggesting this batch captures proliferating/active mast cell states; M100 may represent the antigen presentation arm of activated mast cells.
Genes
Most correlated modules
- OxPhos & RNA Processing · correlation 0.92
- Proliferation RNA Processing · correlation 0.89
- S-phase DNA Replication · correlation 0.87
- Inflammasome Activation · correlation 0.86
- Mixed Housekeeping · correlation 0.86
- Proteostasis & Translation · correlation 0.84
- Mast Cell Signaling · correlation 0.79
- Mitochondrial OxPhos · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.