Mitochondrial OxPhos
Gene co-expression module in Mast cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes COX5A, NDUFB1, ATP5ME, ATP5F1E, SLC25A5 (ANT2), COX7A2, TIMM13 are all mitochondrial — Complex IV, Complex I, ATP synthase, mitochondrial carrier, and import machinery. ELOB (elongin B) is ubiquitin-like. LSM7 is an Sm-like RNA splicing factor. UBL5 is ubiquitin-like. SEC61B is the ER translocon beta subunit. POLR2L is the smallest RNA Pol II subunit. GNG5 is a G-protein gamma subunit. TMEM258 is an ER membrane protein. EIF3J is a translation initiation factor. GMFG is an actin regulatory protein (glia maturation factor gamma). PCBD1 is a pterin-4a-carbinolamine dehydratase. This module has a strong mitochondrial OxPhos core with peripheral RNA/ER components. Significantly upregulated in UC inflammation. Neighbor context: shares OxPhos identity with M170 and M56.
Genes
Most correlated modules
- Mast Cell Identity · correlation 0.93
- Mixed Housekeeping · correlation 0.90
- Proteostasis & Translation · correlation 0.89
- OxPhos & RNA Processing · correlation 0.81
- MHC-II Antigen Presentation · correlation 0.78
- Metabolic Redox Stress · correlation 0.77
- Inflammatory Mast Activation · correlation 0.73
- Mitochondrial OxPhos · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.