Proteostasis & Translation
Gene co-expression module in Mast cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 26 genes have a known function matching the annotation |
Why this annotation
Hub genes PSMA7 and PSMD8 are proteasome subunits. EIF2S2 and EIF5B are translation initiation factors. VDAC1 is the mitochondrial outer membrane voltage-dependent anion channel. PARK7 (DJ-1) is an oxidative stress sensor and mitochondrial quality control protein. GPX4 is a glutathione peroxidase critical for ferroptosis defense. COX7B is a Complex IV subunit. MRPS15 is a mitochondrial ribosomal protein. ARPC2 is an Arp2/3 actin nucleation complex subunit. COPS9 is part of the COP9 signalosome (ubiquitin pathway). HNRNPM is an RNA binding protein. SET inhibits PP2A. PIN1 is a peptidyl-prolyl isomerase. This module combines proteasome/ubiquitin, translation, and mitochondrial components — a broad protein homeostasis/proteostasis program. Slightly upregulated in UC inflammation.
Genes
Most correlated modules
- Mitochondrial OxPhos · correlation 0.89
- Mixed Housekeeping · correlation 0.86
- OxPhos & RNA Processing · correlation 0.84
- MHC-II Antigen Presentation · correlation 0.84
- Inflammatory Mast Activation · correlation 0.84
- Mast Cell Identity · correlation 0.80
- Proliferation RNA Processing · correlation 0.80
- Mast Cell Activation · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.