Mixed Housekeeping
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 13 of 26 genes have a known function matching the annotation |
Why this annotation
Hub genes include TIMM8B and NDUFS6 (mitochondrial), COPE (COPI vesicle trafficking), MGST2 (glutathione S-transferase), YWHAB (14-3-3 signaling scaffold), ING2 and HDAC1 (chromatin regulation), PPP1CA (phosphatase), TXNDC17 (thioredoxin). This is a mixed housekeeping module combining mitochondrial import, redox homeostasis, vesicle trafficking, and chromatin regulation. Uniform expression across all subsets and moderate detection rate support a constitutive housekeeping identity. Neighbor context: similar to M170 and M176 in containing mitochondrial and RNA processing genes, but M30 is more heterogeneous with chromatin/signaling components.
Genes
Most correlated modules
- Mitochondrial OxPhos · correlation 0.90
- Mast Cell Identity · correlation 0.90
- OxPhos & RNA Processing · correlation 0.87
- MHC-II Antigen Presentation · correlation 0.86
- Proteostasis & Translation · correlation 0.86
- Metabolic Redox Stress · correlation 0.84
- Proliferation RNA Processing · correlation 0.78
- Mast Cell Degranulation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.