OxPhos & RNA Processing
Gene co-expression module in Mast cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include MRPL51 (mitochondrial ribosomal protein), COX8A and COX6C (Complex IV subunits), ATP5IF1 (ATP synthase inhibitory factor), UQCRQ (Complex III), NDUFA2 (Complex I) — forming a strong OxPhos core. Additionally SNRPE (snRNP splicing), HNRNPAB (hnRNP RNA binding), NOP56 (rRNA processing), DDX39A (RNA helicase/splicing), LSM4 (Sm-like RNA processing) contribute an RNA processing component. JPT1 is ribosome-associated. CCT5 is a chaperonin. PSMB3 is proteasomal. The module is dominated by mitochondrial respiratory chain genes co-expressed with RNA processing factors, consistent with a coupled housekeeping/metabolic program. Neighbor context: shares OxPhos genes with M176 and M56, and RNA processing genes with M30.
Genes
Most correlated modules
- Proliferation RNA Processing · correlation 0.95
- MHC-II Antigen Presentation · correlation 0.92
- S-phase DNA Replication · correlation 0.92
- Mixed Housekeeping · correlation 0.87
- Proteostasis & Translation · correlation 0.84
- S-phase Replication · correlation 0.84
- Mitotic Spindle · correlation 0.84
- FA DNA Repair · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.