Hypoxia Stress Response
Gene co-expression module in Mast cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 29 genes have a known function matching the annotation |
Why this annotation
HIF1A is the master transcription factor for hypoxia response. ANXA1 (Annexin A1) is an anti-inflammatory mediator induced under stress and hypoxia. CYCS (cytochrome c) is a mitochondrial protein involved in electron transport and apoptosis signaling. JUND is an AP-1 factor induced by hypoxia and stress. LMNA (Lamin A/C) is a nuclear structural protein. TUBA1A is alpha-tubulin. YWHAZ (14-3-3ζ) is a signaling scaffold involved in stress responses. MYADM is a myeloid differentiation marker. SARAF regulates store-operated calcium entry. IDS is a lysosomal enzyme. SBDS is involved in ribosome biogenesis. The module is moderately upregulated in UC inflammation. HIF1A + ANXA1 + CYCS + JUND suggest a hypoxia-driven stress survival program in mast cells within the inflamed colon microenvironment.
Genes
Most correlated modules
- Mitochondrial Respiratory Complex · correlation 0.91
- NF-κB Activation · correlation 0.86
- LXR/PPAR Repression · correlation 0.85
- Autophagy Stress Response · correlation 0.83
- Mediator-Integrator Transcription · correlation 0.82
- mRNA Processing · correlation 0.82
- Splicing & Transcription · correlation 0.82
- NF-κB Immediate Response · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.