Chromatin Remodeling
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
Top hub genes TASOR (HUSH epigenetic silencing complex), SMARCC2 (SWI/SNF chromatin remodeling ATPase subunit), CDC73 (PAF1 transcription elongation/chromatin), and RBL2 (retinoblastoma-like, chromatin silencing) define a chromatin remodeling and epigenetic regulation program. SEPTIN9, LCP1, and HCLS1 add cytoskeletal/actin components common in hematopoietic cells. PABIR2 (PP2A regulatory) and RNF220 (ubiquitin ligase) support regulatory functions. The chromatin remodeling theme is dominant among hub genes.
Genes
Most correlated modules
- Lysosomal Autophagy · correlation 0.95
- RAS/Rho GTPase Signaling · correlation 0.94
- Mast Cell Identity · correlation 0.93
- Mast Cell Specification · correlation 0.93
- Mast Cell Homeostasis · correlation 0.92
- Chromatin Cell Cycle · correlation 0.92
- Mast Cell Identity · correlation 0.92
- PI3K Inflammatory Signaling · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.