Mast Cell Homeostasis
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 12 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes span peroxisomal lipid metabolism (ABCD3, FAR2), cytoskeletal/actin dynamics (FLNB, MRTFA, SSH1), ion transport (SLC9A1, SLC44A2), NAD biosynthesis (NADSYN1), autophagy (AMBRA1), and TBXAS1 (thromboxane synthase). MRTFA links actin polymerization to transcription. The module reflects a broad mast cell homeostatic metabolic state with peroxisomal lipid processing. TBXAS1 is a canonical mast cell eicosanoid enzyme but is outnumbered by housekeeping/metabolic genes. The uniform expression and moderate detection rate suggest a constitutive program across mast cells.
Genes
Most correlated modules
- RAS/Rho GTPase Signaling · correlation 0.95
- Circadian Clock Regulation · correlation 0.94
- Mast Cell Identity · correlation 0.94
- Glucocorticoid Stress Response · correlation 0.94
- Mast Cell Specification · correlation 0.93
- Autophagy Lysosomal Program · correlation 0.93
- PD-L1 Checkpoint Program · correlation 0.92
- Vesicle ER Trafficking · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.