RAS/Rho GTPase Signaling
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes MAP4K5, RASA1, VAV3, ARHGAP17, PIK3R4, and ARHGAP17 collectively represent RAS/Rho GTPase regulatory signaling. TCF12 and AFF1 add transcriptional regulation, CLK2 adds SR kinase activity, and ABCC1 adds efflux transport. The module shows significant upregulation in CD inflammation. The dominant theme is intracellular RAS/Rho signaling and GTPase regulation, with transcriptional co-regulators as secondary members. Uniform expression across subsets argues against contamination.
Genes
Most correlated modules
- Rho GTPase Signaling · correlation 0.97
- Circadian Clock Regulation · correlation 0.96
- Mast Cell Identity · correlation 0.95
- Mast Cell Homeostasis · correlation 0.95
- Mast Cell Specification · correlation 0.94
- Calcium Store Signaling · correlation 0.94
- Chromatin Remodeling · correlation 0.94
- PI3K Inflammatory Signaling · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.