Mitochondrial OxPhos
Gene co-expression module in Mast cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 16 genes have a known function matching the annotation |
Why this annotation
The top hub genes are COX5B and COX6A1 (mitochondrial Complex IV subunits), with GHITM (mitochondrial transmembrane protein), GAPDH and TPI1 (glycolysis), PA2G4 (ribosome biogenesis), PSMA2 (proteasome), and KDELR2 (ER retention). Uniform expression across all subsets and the mix of core metabolic/housekeeping machinery (OxPhos, glycolysis, proteasome, ER) indicate a general metabolic housekeeping program rather than a specific biological response. No disease association is significant. The dominant mitochondrial OxPhos hub genes (COX5B, COX6A1) anchor the module in mitochondrial energy metabolism.
Genes
Most correlated modules
- Actin Cytoskeletal Dynamics · correlation 0.82
- Metabolic Redox Stress · correlation 0.78
- Mast Cell Identity · correlation 0.73
- Mitochondrial OxPhos · correlation 0.72
- Mast Cell Identity · correlation 0.71
- Mast Cell Signaling · correlation 0.65
- Housekeeping Maintenance · correlation 0.65
- Immune Checkpoint State · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.