Circadian Transcription
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
Top hub CRY1 is a core circadian clock gene; NFATC2 is a calcium-regulated transcription factor active in mast cells; PIM2 is a survival kinase; AFF4 is part of the super elongation complex; BTAF1 regulates TATA-binding protein. The module is significantly upregulated in CD inflammation. The combination of CRY1-driven circadian regulation with NFATC2-mediated transcriptional activation suggests a circadian-gated transcriptional program in mast cells, consistent with known circadian control of immune gene expression.
Genes
Most correlated modules
- Transcriptional Metabolic Regulation · correlation 0.96
- Inflammatory IRAK3-BATF Response · correlation 0.95
- ER Protein Quality Control · correlation 0.93
- NF-κB Stress Signaling · correlation 0.93
- Mitochondrial Fusion Stress · correlation 0.92
- Circadian Clock Regulation · correlation 0.92
- Autophagy Lysosomal Program · correlation 0.92
- Ubiquitin-Chromatin Regulation · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.