Transcriptional Metabolic Regulation
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes include REPS1 (endocytic/signaling scaffold), AASS (lysine catabolism), HECA (hematopoietic progenitor marker), EPC1 (Polycomb-associated chromatin regulator), RBBP6 (RNA processing/ubiquitin), RBM14 (RNA binding), CHKA (choline kinase, phospholipid synthesis), F2RL2 (PAR3 protease-activated receptor), PELI1 (E3 ligase in TLR/NF-kB signaling), NRF1 (mitochondrial biogenesis transcription factor), CRTC3 (CREB coactivator, metabolic regulation), SLC25A27 (mitochondrial uncoupling). The module is heterogeneous, combining transcriptional regulation (EPC1, NRF1, CRTC3), RNA processing (RBM14, RBBP6), and metabolic genes. PELI1 and F2RL2 add immune/signaling context. This appears to be a mixed transcriptional/metabolic housekeeping module.
Genes
Most correlated modules
- Circadian Transcription · correlation 0.96
- Cytoskeletal Remodeling · correlation 0.94
- Circadian Clock Regulation · correlation 0.94
- Glucocorticoid Stress Response · correlation 0.94
- Inflammatory IRAK3-BATF Response · correlation 0.93
- PD-L1 Checkpoint Program · correlation 0.93
- Mast Cell Homeostasis · correlation 0.92
- Mast Cell Identity · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.