Cytoskeletal Adhesion Signaling
Gene co-expression module in Mast cells
| Category | migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes include HOOK3 (microtubule-actin crosslinker), CTNNB1 (beta-catenin, Wnt signaling and adhesion), VCL (vinculin, focal adhesion), JARID2 (Polycomb chromatin regulator), BIRC2 (IAP anti-apoptotic), STK4 (Hippo pathway kinase), and PDE4A (cAMP phosphodiesterase). LPXN (leupaxin) is a focal adhesion/paxillin-family protein. The combination of cytoskeletal/adhesion genes (HOOK3, VCL, LPXN, FNBP1) with signaling regulators (CTNNB1, STK4, PDE4A) and chromatin factors (JARID2) suggests a mixed module. The dominant theme across hub genes is cytoskeletal organization and cell adhesion, with CTNNB1 linking to Wnt/adhesion. Positive correlation with UC inflammation supports an activation-associated adhesion/migration program.
Genes
Most correlated modules
- Transcription & Splicing · correlation 0.89
- General Housekeeping · correlation 0.85
- MAPK-AP1 Signaling · correlation 0.85
- NF-κB Activation · correlation 0.84
- NF-κB Inflammatory Signaling · correlation 0.83
- RAS/MAPK Signaling · correlation 0.83
- Cytokine Receptor Signaling · correlation 0.82
- RNA-binding Regulation · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.