Cytokine Receptor Signaling
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 21 genes have a known function matching the annotation |
Why this annotation
MALT1 (paracaspase in NF-κB/BCR signaling), RARA (retinoic acid receptor), IL4R (IL-4 receptor), HIVEP1 (NF-κB-related TF), PMEPA1 (TGF-β target), LACC1 (mast cell/macrophage immune function), TNFAIP8 (anti-apoptotic NF-κB target), ZNF267 (transcriptional regulator), RELT (TNF receptor family), and CLCN3 (chloride channel in immune cells) collectively reflect cytokine receptor and immune regulatory signaling. The module is a neighbor to the NF-κB module M182, consistent with shared upstream immune activation. Lower coherence and mixed membership suggest a broader immune regulatory program rather than a single tight pathway.
Genes
Most correlated modules
- NF-κB Inflammatory Signaling · correlation 0.86
- NF-κB Activation · correlation 0.84
- mRNA Processing · correlation 0.83
- MAPK-AP1 Signaling · correlation 0.82
- NF-κB Activation · correlation 0.82
- Cytoskeletal Adhesion Signaling · correlation 0.82
- RNA-binding Regulation · correlation 0.78
- Transcription & Splicing · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.