MAPK-AP1 Signaling
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 26 genes have a known function matching the annotation |
Why this annotation
Hub genes FOSL2 (Fra-2, AP-1 subunit) and MAPK1 (ERK2) define a MAPK-AP1 signaling axis. VEGFA is a key angiogenic cytokine induced by MAPK/AP-1 signaling. PAK1 is a p21-activated kinase downstream of Rac/Cdc42 that feeds into MAPK. CYTH3 is a cytohesin ARF-GEF involved in integrin/MAPK signaling. ID2 is a helix-loop-helix factor regulated by MAPK. GPR65 is a proton-sensing GPCR on immune cells. SLC7A5 (LAT1) is an amino acid transporter upregulated in activated immune cells. RFTN1 is a lipid raft protein involved in immune receptor signaling. TMOD3 and PDLIM5 are cytoskeletal regulators. As a neighbor to M47 (which contains FOSL1), these two modules together represent the AP-1 transcriptional program in activated mast cells.
Genes
Most correlated modules
- NF-κB Activation · correlation 0.87
- Cytoskeletal Adhesion Signaling · correlation 0.85
- Mast Cell Activation · correlation 0.85
- General Housekeeping · correlation 0.85
- Cytokine Receptor Signaling · correlation 0.82
- NF-κB Activation · correlation 0.81
- NF-κB Immediate Response · correlation 0.80
- NFAT Mast Cell Activation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.