NF-κB Activation
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes RELB and NFKB1 are canonical NF-κB transcription factors. Supporting genes include TIPARP (PARP induced by inflammatory signals), STX11 (vesicle trafficking), RAB8B (vesicle GTPase), ADGRE5 (immune cell adhesion GPCR), SIK3 (immune kinase), PDCD4 (translation/apoptosis regulator), and GABPB1 (transcription factor). Module is significantly upregulated in UC inflammation and reduced in remission, consistent with NF-κB-driven inflammatory activation. As a neighbor to M155 (which contains NFKBIZ, NFKBIA, TNFAIP3), M65 likely represents the upstream NF-κB activation arm while M155 represents the feedback/target gene arm.
Genes
Most correlated modules
- LXR/PPAR Repression · correlation 0.94
- Mast Cell Activation · correlation 0.88
- mRNA Processing · correlation 0.88
- RNA & Protein Homeostasis · correlation 0.87
- MAPK-AP1 Signaling · correlation 0.87
- Autophagy Stress Response · correlation 0.86
- Hypoxia Stress Response · correlation 0.86
- Cytoskeletal Adhesion Signaling · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.