RAS/MAPK Signaling
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include KRAS and RALGDS (RAS pathway effector), MOK (MAPK-related kinase), F2R (PAR-1 thrombin receptor relevant to mast cell activation), PLAAT3 (phospholipase/lipid metabolism), UCP2 (mitochondrial uncoupling), PDGFA (growth factor signaling), and TPPP (microtubule). The module centers on RAS/MAPK signaling with contributions from lipid metabolism and receptor signaling. Low expression and uniform distribution suggest a basal signaling state rather than activation. Decreased in UC remission suggests mild inflammatory relevance.
Genes
Most correlated modules
- Mitochondrial Respiratory Complex · correlation 0.85
- Transcription & Splicing · correlation 0.84
- NF-κB Inflammatory Signaling · correlation 0.84
- General Housekeeping · correlation 0.83
- Cytoskeletal Adhesion Signaling · correlation 0.83
- ER Stress UPR · correlation 0.82
- RNA-binding Regulation · correlation 0.77
- Hypoxia Stress Response · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.