NF-κB Inflammatory Signaling
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 26 genes have a known function matching the annotation |
Why this annotation
Hub genes include HIPK1 (homeodomain-interacting protein kinase), BRAF (MAPK pathway kinase), NFKB2 (NF-κB transcription factor subunit), CREM (cAMP-responsive element modulator), PPP1CB (protein phosphatase), and LRRFIP1 (innate immune signaling). The module shows strong positive correlation with UC inflammation (delta_inflammation_UC=0.701) and negative correlation with remission (delta_remission_UC=-0.683), suggesting an inflammation-associated signaling program. NFKB2, BRAF, CREM, HIPK1, SDCBP, RAP1B, and LRRFIP1 all participate in inflammatory signal transduction and NF-κB pathway regulation. PHF20 and KMT2E are chromatin regulators that can modulate inflammatory gene expression. The module is uniformly expressed across subsets, consistent with a general mast cell inflammatory signaling state rather than contamination.
Genes
Most correlated modules
- RNA-binding Regulation · correlation 0.93
- Cytokine Receptor Signaling · correlation 0.86
- RAS/MAPK Signaling · correlation 0.84
- Endosomal Vesicle Trafficking · correlation 0.84
- NF-κB Activation · correlation 0.83
- Cytoskeletal Adhesion Signaling · correlation 0.83
- mRNA Processing · correlation 0.83
- NF-κB Activation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.