RNA-binding Regulation
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 35 genes have a known function matching the annotation |
Why this annotation
Hub genes include STAU1 (RNA-binding/stress granule protein), DDX27 (RNA helicase), HNRNPR, HNRNPA3, RBM4 (hnRNP family RNA-binding proteins), alongside RAB11FIP1 and ARFGAP3 (vesicle trafficking), NAMPT (NAD+ biosynthesis/signaling), and GNA15 (G-protein). The dominant theme across the highest-PageRank genes is RNA-binding and post-transcriptional regulation, with secondary contributions from intracellular trafficking. The module is uniformly expressed with no subset enrichment, suggesting a general mast cell housekeeping/RNA regulatory program. Negative delta_remission_UC hints at mild disease-state modulation.
Genes
Most correlated modules
- NF-κB Inflammatory Signaling · correlation 0.93
- Protein Biogenesis Housekeeping · correlation 0.87
- NF-κB Activation · correlation 0.79
- Cytoskeletal Adhesion Signaling · correlation 0.79
- Cytokine Receptor Signaling · correlation 0.78
- mRNA Processing · correlation 0.78
- RAS/MAPK Signaling · correlation 0.77
- Pre-mRNA Splicing · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.