PD-L1 Checkpoint Program
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
CD274 (PD-L1) is the top immune checkpoint ligand suppressing T-cell responses. HDAC4 is a class IIa HDAC that represses inflammatory gene expression and can regulate PD-L1. BCL2L11/BIM is a pro-apoptotic BH3-only protein. RRM2B is a p53-inducible ribonucleotide reductase subunit involved in DNA damage response. ARHGAP26 and ELMO1 regulate Rho GTPases and phagocytosis. FER kinase and PIP4K2A regulate PI signaling. MAP4K3 is a stress-activated kinase. The co-expression of PD-L1 with HDAC4 and apoptosis regulators suggests a mast cell immune checkpoint/survival regulatory program, potentially relevant to immune tolerance in the colon.
Genes
Most correlated modules
- Circadian Clock Regulation · correlation 0.95
- Mast Cell Identity · correlation 0.94
- RAS/Rho GTPase Signaling · correlation 0.93
- Transcriptional Metabolic Regulation · correlation 0.93
- Mast Cell Homeostasis · correlation 0.92
- Mitochondrial Fusion Stress · correlation 0.92
- Ubiquitin-Chromatin Regulation · correlation 0.92
- Rho GTPase Signaling · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.