Mitochondrial Fusion Stress
Gene co-expression module in Mast cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 13 genes have a known function matching the annotation |
Why this annotation
OPA1 is the master regulator of mitochondrial inner membrane fusion, NSUN4 is a mitochondrial rRNA methyltransferase essential for mitoribosome assembly, BACH1 is a transcription factor that represses heme oxygenase and antioxidant genes and is regulated by oxidative stress. ACTR1B (ARP1B) is part of dynactin involved in mitochondrial transport. ZBTB10 is a transcriptional repressor. MED26 is a Mediator subunit. SLC26A2 is a sulfate/anion transporter. The module is upregulated in CD inflammation. The mitochondrial genes (OPA1, NSUN4) and oxidative stress regulator (BACH1) suggest a mitochondrial integrity/oxidative stress program.
Genes
Most correlated modules
- Ubiquitin-Chromatin Regulation · correlation 0.93
- Circadian Transcription · correlation 0.92
- PD-L1 Checkpoint Program · correlation 0.92
- Calcium Store Signaling · correlation 0.90
- Transcriptional Metabolic Regulation · correlation 0.89
- Autophagy Lysosomal Program · correlation 0.89
- Innate Immune Stress · correlation 0.89
- ER Protein Quality Control · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.