Lysosomal Autophagy
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 26 genes have a known function matching the annotation |
Why this annotation
Several hub genes point to lysosomal biology: MANBA (lysosomal beta-mannosidase), CLN3 (lysosomal membrane protein, neuronal ceroid lipofuscinosis), GBA1 (lysosomal glucocerebrosidase). BECN1 encodes Beclin-1, a core autophagy regulator. Additional genes include BLTP1 (bridge-like lipid transfer, ER-lysosome contacts), MBOAT1 (lipid acyltransferase), DDX39B (RNA helicase/splicing), NSUN2 (RNA m5C methyltransferase), TYW1 (tRNA modification), SKIC2 (cytoplasmic RNA surveillance). The lysosomal/autophagy cluster (MANBA, CLN3, GBA1, BECN1) is the most coherent biological theme, relevant to mast cell granule biogenesis and lysosomal degradation. RNA processing genes may reflect co-regulated housekeeping. Neutral disease scores suggest a constitutive program.
Genes
Most correlated modules
- Chromatin Remodeling · correlation 0.95
- Mast Cell Identity · correlation 0.93
- Protein Homeostasis · correlation 0.93
- MARCH Ubiquitin Ligase · correlation 0.92
- RAS/Rho GTPase Signaling · correlation 0.92
- Aminoacyl-tRNA Synthetase · correlation 0.92
- Epigenetic Transcriptional Control · correlation 0.92
- Circadian Clock Regulation · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.