Histone Variant Chromatin
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes include MACROH2A1 (macroH2A histone variant, chromatin silencing/X-inactivation), H2AZ1 (H2A.Z histone variant, active chromatin), H4C3 (histone H4), SEPTIN8/SEPTIN1 (cytoskeletal septins), KARS1 (aminoacyl-tRNA synthetase), ADSS2 (purine biosynthesis), COA8 (mitochondrial complex IV assembly), STING1 (innate immune cGAS-STING sensor), and NHEJ1 (non-homologous end joining). All disease deltas are zero, suggesting constitutive expression. The histone variants (MACROH2A1, H2AZ1, H4C3) and chromatin-associated genes are the most coherent subgroup. The module appears to represent a constitutive chromatin/histone variant program with mixed housekeeping genes.
Genes
Most correlated modules
- General Housekeeping · correlation 0.96
- Protein Homeostasis · correlation 0.91
- Aminoacyl-tRNA Synthetase · correlation 0.90
- Mitochondrial Organization · correlation 0.90
- RNA Processing & Mitochondrial · correlation 0.90
- MARCH Ubiquitin Ligase · correlation 0.88
- tRNA Aminoacylation · correlation 0.88
- Aminoacyl-tRNA Synthetases · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.