Mast Cell Identity
Gene co-expression module in Mast cells
| Category | Mast cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes include ZBTB16 (PLZF), a master transcription factor for mast cell identity and development; KLF13, expressed in mast cells and lymphocytes; SLA, a Src-like adaptor modulating immune receptor signaling; ITPR1, mediating calcium release downstream of mast cell activation; JADE2, involved in chromatin/histone regulation; and PARP4 for DNA repair. ZFP36L2 is an RNA-binding protein regulating mast cell quiescence. The module is elevated in UC inflammation and reduced in remission, consistent with mast cell identity genes being upregulated in active disease. TNIK and RCSD1 contribute cytoskeletal/signaling support. This module reflects core mast cell transcriptional identity and homeostatic signaling programs.
Genes
Most correlated modules
- RAS/Rho GTPase Signaling · correlation 0.95
- Glucocorticoid Stress Response · correlation 0.95
- Mast Cell Homeostasis · correlation 0.94
- Rho GTPase Signaling · correlation 0.94
- PD-L1 Checkpoint Program · correlation 0.94
- Mast Cell Identity · correlation 0.94
- Circadian Clock Regulation · correlation 0.94
- Chromatin Remodeling · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.