Endosomal Vesicle Trafficking
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include CHMP2B (ESCRT-III, endosomal sorting/multivesicular body), SNX2 (sorting nexin, endosomal trafficking), GCC2 (Golgi coiled-coil protein, vesicle tethering), GOSR1 (Golgi SNARE), UBE2B (ubiquitin-conjugating enzyme), UBXN10 (UBX domain, ubiquitin regulatory), and HSPA9 (mitochondrial chaperone). The module is dominated by endosomal/vesicular trafficking machinery (CHMP2B, SNX2, GCC2, GOSR1) combined with ubiquitin pathway components (UBE2B, UBXN10). This represents an endosomal sorting and vesicle trafficking program. The disease correlations are modest and non-significant, consistent with a housekeeping-adjacent trafficking function.
Genes
Most correlated modules
- NF-κB Inflammatory Signaling · correlation 0.84
- RNA-binding Regulation · correlation 0.73
- Cytokine Receptor Signaling · correlation 0.73
- ER Stress UPR · correlation 0.73
- Mediator-Integrator Transcription · correlation 0.71
- RAS/MAPK Signaling · correlation 0.69
- NF-κB Activation · correlation 0.67
- Protein Biogenesis Housekeeping · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.