mRNA Processing
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes HNRNPH3, PAPOLA, HNRNPC, and PAIP2 are all RNA-binding proteins involved in mRNA processing, polyadenylation, and translation regulation. These represent the dominant program. Additional genes (VIM, TAGLN2, EZR, DCTN6) are cytoskeletal, and SLC25A3 is mitochondrial, making this a mixed housekeeping module. PER2 (circadian) and BCL7B (chromatin) are peripheral. RNA processing genes dominate the top PageRank positions.
Genes
Most correlated modules
- NF-κB Activation · correlation 0.88
- Cytokine Receptor Signaling · correlation 0.83
- NF-κB Inflammatory Signaling · correlation 0.83
- RNA & Protein Homeostasis · correlation 0.83
- Hypoxia Stress Response · correlation 0.82
- LXR/PPAR Repression · correlation 0.82
- Transcription & Splicing · correlation 0.81
- ER Stress UPR · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.