NF-κB Activation
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 16 genes have a known function matching the annotation |
Why this annotation
This is an extremely tight module (all genes core membership) centered on canonical NF-κB signaling. NFKBID (IκBNS, NF-κB modulator), REL (c-Rel, NF-κB subunit), BCL3 (IκB family NF-κB coactivator), BIRC3 (IAP, NF-κB target anti-apoptotic), BCL2A1 (NF-κB target survival gene), ICAM1 (NF-κB target adhesion molecule), CD83 (NF-κB target activation marker), KDM6B (H3K27me3 demethylase, inflammation-induced), NFE2L2 (NRF2, stress/inflammation TF), ZC3H12A (Regnase-1, mRNA decay dampening inflammation), KLF10 (TGF-β/inflammation TF), and MAPK6 all participate in inflammatory transcriptional responses. The strong delta_remission_UC signal supports active inflammatory activation. Neighbor to M62 (cytokine receptor signaling), consistent with shared NF-κB upstream activation.
Genes
Most correlated modules
- Cytokine Receptor Signaling · correlation 0.84
- NF-κB Inflammatory Signaling · correlation 0.83
- MAPK-AP1 Signaling · correlation 0.81
- Pre-mRNA Splicing · correlation 0.80
- RNA-binding Regulation · correlation 0.79
- Mast Cell Activation · correlation 0.75
- TGF-beta Repression · correlation 0.69
- ER Stress UPR · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.