ER Stress UPR
Gene co-expression module in Mast cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes are canonical unfolded protein response (UPR)/ER stress markers: HSP90B1 (GRP94, ER chaperone), HSPA5 (BiP/GRP78, master UPR regulator), HERPUD1 (ERAD component, ERAD-induced by UPR), XBP1 (key UPR transcription factor, IRE1 branch), and DNAJB11 (ER-localized co-chaperone). This is a tightly coherent, high-confidence ER stress/UPR module. The strong negative correlation with UC remission (delta_remission_UC=-0.904) and positive correlation with inflammation (delta_inflammation_UC=0.738) suggest UPR activation is associated with active disease. CEBPG can be induced by UPR. This module is a neighbor to M191 (vesicle trafficking) and M113 (mixed housekeeping/ER), consistent with ER-related programs clustering together.
Genes
Most correlated modules
- NF-κB Inflammatory Signaling · correlation 0.82
- RAS/MAPK Signaling · correlation 0.82
- mRNA Processing · correlation 0.79
- Mitochondrial Respiratory Complex · correlation 0.76
- Hypoxia Stress Response · correlation 0.75
- RNA-binding Regulation · correlation 0.73
- Endosomal Vesicle Trafficking · correlation 0.73
- Cytoskeletal Adhesion Signaling · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.