NF-κB Immediate Response
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 19 genes have a known function matching the annotation |
Why this annotation
This module is a classic NF-κB immediate-early response and negative feedback signature. NFKBIZ (IκBζ) potentiates NF-κB target gene transcription. TNFAIP3 (A20) is the canonical NF-κB negative feedback ubiquitin editor. NFKBIA (IκBα) is the primary NF-κB inhibitor and itself an NF-κB target gene. NR4A1 and NR4A2 are immediate-early nuclear receptors induced by inflammatory stimuli. CSRNP1 is an immediate-early gene. PPP1R15A (GADD34) and PPP1R15B regulate stress responses. MCL1 is an NF-κB-induced anti-apoptotic gene. ELL2 is an RNA Pol II elongation factor induced by NF-κB. PER1 is a circadian gene regulated by NF-κB. IFRD1 is an anti-inflammatory co-regulator. Module is significantly reduced by treatment in both UC and CD, consistent with an inflammatory activation program.
Genes
Most correlated modules
- LXR/PPAR Repression · correlation 0.88
- Endosomal Autophagy Trafficking · correlation 0.87
- NFAT Mast Cell Activation · correlation 0.85
- Autophagy Stress Response · correlation 0.83
- NF-κB Activation · correlation 0.83
- Mast Cell Activation · correlation 0.81
- Hypoxia Stress Response · correlation 0.81
- MAPK-AP1 Signaling · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.