LXR/PPAR Repression
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes include SIN3A (HDAC co-repressor complex), PHF1 (Polycomb repressive complex 2 component), and CHD1 (chromatin remodeler). NR1H2 (LXRβ) and PPARD (PPARδ) are nuclear receptors known to suppress NF-κB and regulate lipid metabolism. HMGCR and HMGCS1 are cholesterol biosynthesis enzymes regulated by LXR. SAP30BP is a Sin3A-associated protein. ZBTB21, PRDM8, ZNF410 are transcriptional repressors. AGPAT4 is a phospholipid biosynthesis enzyme. The module combines chromatin-level transcriptional repression with LXR/PPAR-mediated lipid metabolism — a known counter-regulatory axis to NF-κB inflammation. As a neighbor to M65 (NF-κB activation), this module may represent the opposing transcriptional repression program.
Genes
Most correlated modules
- NF-κB Activation · correlation 0.94
- Autophagy Stress Response · correlation 0.91
- Innate Immune Stress · correlation 0.89
- NF-κB Immediate Response · correlation 0.88
- NF-κB Stress Signaling · correlation 0.88
- RNA & Protein Homeostasis · correlation 0.88
- Endosomal Autophagy Trafficking · correlation 0.86
- ER Protein Quality Control · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.