Mast Cell Activation
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 26 genes have a known function matching the annotation |
Why this annotation
FOSL1 (Fra-1) is an AP-1 transcription factor, complementing FOSL2 in neighboring M180. RELA (p65) is the canonical NF-κB subunit, linking this module to M65 and M155. SRGN (serglycin) is a proteoglycan core protein stored in mast cell secretory granules and a key mast cell activation marker. STK17A is a DRAK kinase involved in apoptosis and immune cell activation. EIF4A1 is a translation initiation factor. JMJD6 is an arginine demethylase involved in RNA splicing and transcriptional regulation. WTAP is an m6A RNA methyltransferase. RBM8A is an exon junction complex component. PLIN2 is a lipid droplet protein. LDLR and GPAT4 are involved in lipid metabolism. The co-occurrence of SRGN with AP-1/NF-κB and RNA processing genes suggests mast cell activation with translational/post-transcriptional upregulation of granule components.
Genes
Most correlated modules
- NF-κB Activation · correlation 0.88
- MAPK-AP1 Signaling · correlation 0.85
- LXR/PPAR Repression · correlation 0.85
- Autophagy Stress Response · correlation 0.84
- NF-κB Immediate Response · correlation 0.81
- RNA & Protein Homeostasis · correlation 0.81
- NFAT Mast Cell Activation · correlation 0.79
- General Housekeeping · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.