Monocyte Chemokine Secretion
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes CCL2 and CCL7 are monocyte-recruiting chemokines (MCP-1 and MCP-3); CXCL11 is an IFN-inducible chemokine; ACOD1 (aconitate decarboxylase 1/IRG1) produces itaconate, a key immunometabolic mediator in inflammatory macrophages; IL27 is an anti-inflammatory/regulatory cytokine produced by activated monocytes; GBP3 is an IFN-induced GBP; CLEC5A is a DAP12-coupled lectin receptor on myeloid cells; ADAM19 is a metalloprotease. The module is strongly upregulated in IBD inflammation and reduced in remission. Very low baseline expression (2.6% positive) suggests activation-specific expression. This represents a classically activated monocyte cytokine/chemokine secretion program with immunometabolic reprogramming (ACOD1).
Genes
ACOD1, ADAM19, CCL2, CCL7, CLEC5A, CXCL11, GBP3, IL27
Most correlated modules
- NF-κB Counter-regulation · correlation 0.87
- IFN-gamma Response · correlation 0.80
- Type I Interferon · correlation 0.78
- TNF/IL-1 Cytokine Storm · correlation 0.77
- TNF-driven Activation · correlation 0.76
- Fc Receptor Activation · correlation 0.67
- Type I Interferon Response · correlation 0.66
- JAK-STAT IFN Signaling · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.