Myeloid Innate Receptor Signaling
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include PILRA (paired immunoglobulin-like receptor A, inhibitory myeloid receptor), LILRA5 (activating leukocyte Ig-like receptor), LILRB2 (inhibitory leukocyte Ig-like receptor), MYD88 (MyD88, central TLR/IL-1R signaling adaptor), HCK (Src-family tyrosine kinase, myeloid innate signaling), SERPINA1 (alpha-1 antitrypsin, anti-inflammatory serine protease inhibitor), CYTIP (cytohesin-interacting protein, integrin/Src signaling), and PAG1 (phosphoprotein associated with glycosphingolipid-enriched microdomains, Src kinase regulator). The LILR/PILRA receptor cluster combined with MYD88 and HCK defines innate myeloid receptor signaling. Upregulated in CD inflammation. Neighbor modules M5 and M17 also feature LILR family members, confirming a shared myeloid receptor signaling neighborhood.
Genes
CYTIP, HCK, JPT1, LILRA5, LILRB2, MYD88, PAG1, PILRA, SERPINA1
Most correlated modules
- Macrophage Differentiation · correlation 0.79
- Non-classical Monocyte · correlation 0.77
- Non-classical Monocyte Migration · correlation 0.75
- Type I Interferon Response · correlation 0.74
- Non-classical Monocyte · correlation 0.73
- IFN-gamma Monocyte Activation · correlation 0.65
- FPR1 Innate Sensing · correlation 0.64
- Autophagy Metabolic Stress · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.