Mitochondrial-biogenesis housekeeping
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 14 of 34 genes have a known function matching the annotation |
Why this annotation
Genes are dominated by general cellular machinery spanning several housekeeping functions. Mitochondrial metabolism: MPC1, MRPS35, COX20, HAGH, ALDH16A1. Ribosome and nucleolar biogenesis: NOL7, TMA16, PPM1G, CCDC12, C9orf78. Chaperonin: TCP1. DNA repair: PARP1. Retromer: VPS35, SNX5. Detection is broad (48%) and uniform with no subset specificity. Together this is consistent with a housekeeping or biosynthetic-capacity axis rather than a specific immune program. BTK and MAPKAPK3 are peripheral signaling members.
Genes
Most correlated modules
- Nonclassical monocyte identity · correlation 0.95
- CD16 Monocyte Signature · correlation 0.95
- Actin-endocytic remodeling · correlation 0.95
- Translation & Actin Maintenance · correlation 0.93
- Non-classical Monocyte Identity · correlation 0.92
- Patrolling Monocyte Cytoskeleton · correlation 0.92
- Myeloid Basal Housekeeping · correlation 0.91
- Classical monocyte identity · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.