Tissue-Resident Macrophage
Gene co-expression module in Monocytes
| Category | Tissue adaptation |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 16 genes have a known function matching the annotation |
Why this annotation
The top hub genes (FOLR2, LYVE1, GPNMB, DAB2, LGMN, LILRB5, SELENOP, PLTP, ITGB5) form the canonical signature of tissue-resident interstitial macrophages. FOLR2 and LYVE1 are well-established markers of anti-inflammatory tissue-resident macrophages; GPNMB, DAB2, LGMN mark phagocytic/homeostatic macrophages; LILRB5 is an inhibitory receptor on tissue-resident macrophages; SELENOP and PLTP are expressed in tissue-resident macrophage populations. The module is core-coherent, uniformly expressed at low levels consistent with a rare differentiated subpopulation within monocyte data. The negative delta in remission may reflect reduced tissue-resident macrophage accumulation during disease resolution.
Genes
DAB2, ETV5, FOLR2, FRMD4A, GPNMB, ITGB5, LGMN, LILRB5, LYVE1, OTOA, PLTP, RAB3IL1, SELENOP, SLC7A8, SLCO2B1, TMEM37
Most correlated modules
- Complement C1q Macrophage · correlation 0.86
- M2 Macrophage Polarization · correlation 0.80
- Efferocytosis Tissue Macrophage · correlation 0.78
- Tissue Macrophage Identity · correlation 0.72
- Monocyte Lipid Handling · correlation 0.68
- IL-18 Inflammasome Response · correlation 0.60
- Tissue-destructive Macrophage · correlation 0.56
- Tissue-Resident Macrophage · correlation 0.43
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.