Proteostasis-trafficking housekeeping
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 19 genes have a known function matching the annotation |
Why this annotation
Mixed housekeeping module covering several protein-handling and mitochondrial functions: - ER translocation/secretory: SPCS1, NACA, TRAPPC1. - ESCRT: CHMP2A, VPS28. - Proteasome: PSMB3. - Antioxidant enzymes: PRDX5, MGST3, GSTO1, TXNDC17. - Complex I: NDUFB7, NDUFC2. - Autophagy: GABARAPL2. Overall this suggests protein homeostasis/trafficking capacity, with uniform expression.
Genes
Most correlated modules
- Respiratory chain OxPhos · correlation 0.96
- Abundant Small Transcripts · correlation 0.95
- Mixed housekeeping metabolism · correlation 0.93
- Myeloid Basal Housekeeping · correlation 0.92
- Translation-OxPhos housekeeping · correlation 0.90
- Complex I OxPhos · correlation 0.88
- Mitochondrial-splicing housekeeping · correlation 0.88
- Translational biosynthesis · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.