Macrophage Differentiation
Gene co-expression module in Monocytes
| Category | Developmental |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include VMO1 (expressed in tissue macrophages/monocytes), MSR1 (macrophage scavenger receptor 1, canonical tissue macrophage marker), TAGLN (transgelin, actin-binding cytoskeletal protein), FMNL2 (formin-like 2, actin cytoskeletal remodeling), MS4A4A (monocyte/macrophage differentiation marker), FCGR3B (CD16b), and IL3RA (CD123). MSR1 and MS4A4A mark monocyte-to-macrophage differentiation. TAGLN and FMNL2 indicate cytoskeletal reorganization associated with tissue residency. Low expression and low pct positive suggest a subset-specific or transitional state. Upregulated in inflammation, reduced in remission.
Genes
C7orf50, CABP4, FCGR3B, FMNL2, IL3RA, MS4A4A, MSR1, PPM1N, PPP1R17, TAGLN, VMO1, ZMYND15
Most correlated modules
- Non-classical Monocyte · correlation 0.85
- Non-classical Monocyte · correlation 0.81
- Autophagy Metabolic Stress · correlation 0.80
- Myeloid Innate Receptor Signaling · correlation 0.79
- Non-classical Monocyte State · correlation 0.77
- Type I Interferon Response · correlation 0.66
- Non-classical Monocyte Migration · correlation 0.65
- Mitochondrial Immune Regulation · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.