Glucocorticoid Transcription
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
KLF9 and KLF13 are glucocorticoid-responsive Krüppel-like factors that mediate anti-inflammatory transcriptional programs in monocytes. PER1 is a core circadian clock gene whose expression is regulated by glucocorticoids and stress. JDP2 (Jun dimerization protein 2) is an AP-1 repressor that suppresses inflammatory gene transcription. ZBTB16 (PLZF) is a transcriptional repressor involved in monocyte differentiation and anti-inflammatory responses. PIK3R1 (p85α) modulates PI3K/Akt signaling. HECTD1 is an E3 ubiquitin ligase. The co-expression of KLF9/KLF13/PER1/JDP2/ZBTB16 defines a glucocorticoid-responsive, anti-inflammatory transcriptional module. Paradoxically upregulated in inflammation — possibly a counter-regulatory response — and reduced in remission.
Genes
HECTD1, JDP2, KLF13, KLF9, PER1, PIK3R1, TMEM123, ZBTB16
Most correlated modules
- Autophagy Initiation · correlation 0.76
- AMPK-FOXO Stress Response · correlation 0.74
- Inflammatory Autophagy · correlation 0.70
- Innate Immune Transcription · correlation 0.66
- Histone Chromatin Remodeling · correlation 0.62
- Glucocorticoid Response · correlation 0.60
- Endosomal Sorting · correlation 0.60
- MET Tissue Repair · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.